TB500 (Thymosin Beta 4)

Overview

TB500 is a 43 amino acid synthetic analogue of thymosin beta 4 (TB4), which is found naturally in nearly all mammalian cells. TB500 is known for its effects on actin protein, cell migration, and wound healing. TB500 has been shown in animal models and in vitro studies to improve blood vessel growth, accelerate wound healing, decrease inflammation, and promote extracellular matrix production. The peptide is under current investigation for its ability to reduce oxidative stress in spinal cord injury, improve recovery following heart attack, and for its many anti-aging effects.

TB500 is the active domain of TB4, which has a primary role as an actin binding protein. Actin is a critical component of cell structure and makes up microfilaments. Microfilaments are responsible for giving cells their shape, protecting the integrity of cell membranes, allowing cells to move/migrate, and certain steps in cellular reproduction. Actin is also one of the primary components of muscle protein. Without actin, muscles could not contract. Actin binding proteins, like TB4, sequester actin monomers, the individual units of actin, so that they are protected from degradation and are available for polymerisation into microfilaments when needed.

Structure

Sequence:  Ac-Ser-Asp-Lys-Pro-Asp-Met-Ala-Glu-Ile-Glu-Lys-Phe-Asp-Lys-Ser-Lys-Leu-Lys-Lys-Thr-Glu-Thr-Gln-Glu-Lys-Asn-Pro-Leu-Pro-Ser-Lys-Glu-Thr-Ile-Glu-Gln-Glu-Lys-Gln-Ala-Gly-Glu-Ser

Molecular Formula: C212H350N56O78S

Molecular Weight: 4963.44 g/mol

PubChem CID: 16132341

CAS Number: 77591-33-4

Synonyms: TB4

Research

Neurologic Function

Blood Vessel Growth

Hair Growth

Antibiotic Synergy

Cardiovascular Health

Neurodegenerative Diseases

Summary

References

Information about specific authors, researchers, and references is available on request.

Certificate of Analysis (COA)

Available to licensed researchers on request.

High Performance Liquid Chromatography (HPLC)

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Mass Spectrometry (MS)

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